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The pattern in trials has been broadly consistent with other incretin-based therapies (such as Mounjaro and Wegovy), and most side effects have been mild to moderate and dose-dependent, occurring mainly during the initial dose-escalation period

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For example, PROTACs could be used to degrade intracellular signal transducers or undruggable protein molecules

[2]Thorens B (1992) Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1

They may also inhibit the growth of new blood vessels that are needed to keep tumors growing

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